6′′-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes
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چکیده
منابع مشابه
6''-Thioether tobramycin analogues: towards selective targeting of bacterial membranes.
Decades of widespread clinical use of the bacterial ribosome A-site-targeting aminoglycosides (AGs) enhanced the evolution of resistance to these antibiotics and reduced their clinical efficacy. Three modes of action lead to bacterial resistance to AGs: reduction in the intracellular concentration of the antibiotics by efflux pump proteins or through reduced membrane permeability; structural mo...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2012
ISSN: 1433-7851
DOI: 10.1002/anie.201200761